Nicolo "Nick" DelGaudio and his brother Gaetano DelGaudio were influential members of the Manhattan Camorra during the 1910s. They apparently worked closely with Giosue Gallucci, the politically connected East Harlem crime boss, and with the remnants of the Morello-Lupo Mafia (Giuseppe Morello and Ignazio Lupo were locked up in Atlanta Federal Prison during the decade). About 1913, the old alliances broke down.
Nicolo resided at 2029 First Avenue in East Harlem. He owned a restaurant nearby at 2023 First Avenue. Authorities believed his restaurant was merely a front for illegal activities. In February 1913, he was suspected of involvement in an unsuccessful attempt on Gallucci's life that resulted in the death of Gallucci bodyguard Tony Capilongo. That spring, Nicolo left the country for a long trip to Italy. He returned in the fall of 1914.
On October 14, 1914, DelGaudio and his friend Tancredi Dellabado met at First Avenue and walked toward a garage where DelGaudio kept his automobile. As they passed a stable at 421 East 104th Street, a gunshot was heard. DelGaudio fell mortally wounded, and Dellabado ran off. Police later found a shotgun inside an upstairs front window over the stable. Along with it was a hat they traced to Francisco Ruggiero of 403 East 106th Street. Ruggiero was arrested.
Gaetano DelGaudio managed to remain alive for another two years. In the early morning hours of November 30, 1916, he was shot while working in his restaurant, 2031 First Avenue. He died a short time later in a hospital, after refusing to name his murderer.